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Correction
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Correction

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Original Article
Open access

The cryo-EM structure of the BoNT/Wo-NTNH complex reveals two immunoglobulin-like domains

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BoNT/Wo is a newly identified BoNT-like toxin. It forms a complex with its NTNH partner, which in traditional BoNTs exhibits a protective function. The overall structural arrangement is similar to other BoNT-NTNH complexes. However, NTNH/Wo uniquely contains two extra bacterial immunoglobulin-like domains, which could be involved in toxin delivery to the target cells. Mass photometry revealed that the BoNT/Wo-NTNH/Wo complex is stable under acidic conditions and dissociates at neutral to basic pH.

Commentary
Open access

An innate immune sensor wandering around – NOD1 promotes cell migration via non-canonical signaling

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NOD1 is a cytosolic immune receptor that recognizes intracellular bacteria, inducing innate immune responses. Upon ligand binding, it forms a complex with RIPK2 to activate NF-κB. Additionally, NOD1 has been associated with cancer progression. Hezinger et al. investigated a non-canonical role of NOD1 in cell migration and discovered that Nod1 is crucial for the migration and chemotaxis of HeLa cells and identified HAX-1 as a novel interaction partner.

Comment on: https://doi.org/10.1111/febs.16912.

Mini Review
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The regulation of liquid‐liquid phase separated condensates containing nucleic acids

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Condensates are formed by liquid–liquid phase separation, and mediated by weak, multivalent intermolecular interactions. In condensates, biomolecules have high concentrations, and many biological processes involving nucleic acids occur. In this review, we mainly summarize the regulation of phase-separated condensates containing nucleic acids by the nature of proteins and the properties of nucleic acids, and speculate the possible potential of phase-separated condensates as a drug target.

Commentary
Open access

Seek and you shall find—news on the quest for novel PET-degrading enzymes

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Plastic-degrading enzymes hold promise for eco-friendly recycling methods. However, their catalytic rates are inadequate to degrade the millions of tons of plastic waste produced yearly. Zhang et al. reported the discovery of PET40, a versatile PET-hydrolyzing esterase. While PET40 has a comparably low hydrolytic activity on PET, they demonstrate its broad activity on an expanded substrate pool, shedding light on its potential ecological role and suggesting that PET might be only a recent addition to its substrate spectrum.

Comment on: https://doi.org/10.1111/febs.16924.

Original Article

GR-KLF15 pathway controls hepatic lipogenesis during fasting

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During fasting, the body stops lipogenesis by suppressing sterol regulatory element-binding protein-1 (SREBP-1). Fasting-induced Kruppel-like factor 15 (KLF15) interacts with liver X receptor to regulate SREBP-1 expression. Glucocorticoid receptor (GR) induces KLF15 and suppresses lipogenesis via KLF15-SREBP-1. The necessity of KLF15 for SREBP-1 suppression was confirmed in a KLF15 knockout mouse model. Thus, the hypothalamic–pituitary–adrenal-axis-regulated GR-KLF15 pathway plays a critical role in the regulation of lipid metabolism in the fasting liver.

Corrigendum
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Corrigendum

No abstract is available for this article.
Original Article

Novel tetrahydrofolate-dependent d-serine dehydratase activity of serine hydroxymethyltransferases

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In addition to their canonical hydroxymethyltransferase activity, human and E. coli serine hydroxymethyltransferases (SHMTs) were found to exhibit novel d-serine dehydratase activity, which degrades d-serine to pyruvate and ammonia and requires tetrahydrofolate. This activity is critical, because the growth of an SHMT-deficient E. coli strain was significantly impaired in the presence of d-serine. We propose a possible reaction mechanism for d-serine dehydration by SHMTs and suggest that they play an important physiological role in d-serine metabolism.

Review
Open access

From molecular basis to clinical insights: a challenging future for the vitamin D endocrine system in colorectal cancer

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Here, we review the variety of molecular mechanisms underlying the antitumor effects of the vitamin D endocrine system in colorectal cancer (CRC), which affect multiple processes that are dysregulated during tumor initiation and progression. Additionally, we discuss the epidemiological data that associate vitamin D deficiency and CRC, and the most relevant randomized controlled trials of vitamin D3 supplementation conducted in both healthy individuals and CRC patients.

Original Article

Simultaneous structural replacement of the sphingoid long‐chain base and sterol in budding yeast

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The basic structures of sphingolipids and sterols differ among species; however, the physiological significance is not well understood. In this study, we performed simultaneous replacement of long-chain base structure of sphingolipids and sterol to mammalian types in budding yeast and found that the simultaneous replacement can compensate the growth of yeast but causes multiple stress hypersensitivity and abnormal plasma membrane and cell wall properties.

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