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Volume 325, Issue 1-2 p. 86-89
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ATP - a fast neurotransmitter

Frances A. Edwards

Frances A. Edwards

Department of Pharmacology, University of Sydney, NSW 2006, Australia

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Alasdair J. Gibb

Alasdair J. Gibb

Department of Pharmacology, University College London, Gower St., London WC1E 6BT, UK

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First published: June 28, 1993
Citations: 123
Correspondence address: Alasdair J. Gibb, Department of Pharmacology, University College London, Gower St., London WC1E 6BT, UK.

Abstract

ATP receptor-mediated responses in peripheral and central neurones have many characteristics which suggest that ATP may act as a fast neurotransmitter. While the receptors underlying these responses have properties which are similar to other ligand-gated ion channels which mediate fast neurotransmision, the nature of their calcium permeability and the rapid breakdown of ATP to adenosine may confer unique properties on ATP mediated synaptic transmission. The evidence that ATP acts as a fast neurotransmitter is reviewed and the properties of ATP and its receptor channels are discussed in terms of synaptic transmission.