Journal list menu

Volume 315, Issue 3 p. 318-322
Research letters
Free Access

The rat delta-1 and delta-2 subunits extend the excitatory amino acid receptor family

H. Lomeli

H. Lomeli

Laboratory of Molecular Neuroscience, Center for Molecular Biology (ZMBH), Heidelberg University, INF282, D-6900 Heidelberg, Germany

Search for more papers by this author
R. Sprengel

R. Sprengel

Laboratory of Molecular Neuroscience, Center for Molecular Biology (ZMBH), Heidelberg University, INF282, D-6900 Heidelberg, Germany

Search for more papers by this author
D.J. Laurie

D.J. Laurie

Laboratory of Molecular Neuroscience, Center for Molecular Biology (ZMBH), Heidelberg University, INF282, D-6900 Heidelberg, Germany

Search for more papers by this author
G. Köhr

G. Köhr

Laboratory of Molecular Neuroscience, Center for Molecular Biology (ZMBH), Heidelberg University, INF282, D-6900 Heidelberg, Germany

Search for more papers by this author
A. Herb

A. Herb

Laboratory of Molecular Neuroscience, Center for Molecular Biology (ZMBH), Heidelberg University, INF282, D-6900 Heidelberg, Germany

Search for more papers by this author
P.H. Seeburg

Corresponding Author

P.H. Seeburg

Laboratory of Molecular Neuroscience, Center for Molecular Biology (ZMBH), Heidelberg University, INF282, D-6900 Heidelberg, Germany

Correspondence address: P.H. Seeburg, Laboratory of Molecular Neuroscience, Center for Molecular Biology (ZMBH), Heidelberg University, INF 282, D-6900 Heidelberg, Germany. Fax: (49) (6221) 565 894.Search for more papers by this author
W. Wisden

W. Wisden

Laboratory of Molecular Neuroscience, Center for Molecular Biology (ZMBH), Heidelberg University, INF282, D-6900 Heidelberg, Germany

Search for more papers by this author
First published: January 11, 1993
Citations: 267

Abstract

We have characterized a second member (delta-2) of a new class of subunits for the ligand-gated excitatory amino acid receptor superfamily. The sequence of delta-2 exhibits an average identity of 25% and 18.5% to the non-NMDA and NMDA receptor subunits, respectively. The rat delta-2 gene is expressed predominantly in Purkinje cells of the cerebellum whereas only low levels of delta-1 transcripts are found in the adult brain. However, delta-1 gene expression undergoes a pronounced developmental peak, with particularly high mRNA levels in the caudate putamen of late embryonic/early postnatal stages.