Volume 325, Issue 3 p. 167-172

Research letters

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Glycogen synthase kinase 3β is identical to tau protein kinase I generating several epitopes of paired helical filaments

Koichi Ishiguro,

Koichi Ishiguro

Mitsubishi Kasei Institute of Life Sciences, 11 Minamiooya, Machidashi, Tokyo 194, Japan

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Akiko Shiratsuchi,

Akiko Shiratsuchi

Mitsubishi Kasei Institute of Life Sciences, 11 Minamiooya, Machidashi, Tokyo 194, Japan

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Showbu Sato,

Showbu Sato

Mitsubishi Kasei Institute of Life Sciences, 11 Minamiooya, Machidashi, Tokyo 194, Japan

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Akira Omori,

Akira Omori

Mitsubishi Kasei Institute of Life Sciences, 11 Minamiooya, Machidashi, Tokyo 194, Japan

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Manabu Arioka,

Manabu Arioka

Department of Agricultural Chemistry, University of Tokyo, Bunkyoku, Tokyo 113, Japan

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Shunsuke Kobayashi,

Shunsuke Kobayashi

College of Pharmacy, Nihon University, Narashinodai, Funabashishi, Chiba 274, Japan

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Tsuneko Uchida,

Tsuneko Uchida

Mitsubishi Kasei Institute of Life Sciences, 11 Minamiooya, Machidashi, Tokyo 194, Japan

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Kazutomo Imahori,

Kazutomo Imahori

Mitsubishi Kasei Institute of Life Sciences, 11 Minamiooya, Machidashi, Tokyo 194, Japan

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Koichi Ishiguro,

Koichi Ishiguro

Mitsubishi Kasei Institute of Life Sciences, 11 Minamiooya, Machidashi, Tokyo 194, Japan

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Akiko Shiratsuchi,

Akiko Shiratsuchi

Mitsubishi Kasei Institute of Life Sciences, 11 Minamiooya, Machidashi, Tokyo 194, Japan

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Showbu Sato,

Showbu Sato

Mitsubishi Kasei Institute of Life Sciences, 11 Minamiooya, Machidashi, Tokyo 194, Japan

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Akira Omori,

Akira Omori

Mitsubishi Kasei Institute of Life Sciences, 11 Minamiooya, Machidashi, Tokyo 194, Japan

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Manabu Arioka,

Manabu Arioka

Department of Agricultural Chemistry, University of Tokyo, Bunkyoku, Tokyo 113, Japan

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Shunsuke Kobayashi,

Shunsuke Kobayashi

College of Pharmacy, Nihon University, Narashinodai, Funabashishi, Chiba 274, Japan

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Tsuneko Uchida,

Tsuneko Uchida

Mitsubishi Kasei Institute of Life Sciences, 11 Minamiooya, Machidashi, Tokyo 194, Japan

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Kazutomo Imahori,

Kazutomo Imahori

Mitsubishi Kasei Institute of Life Sciences, 11 Minamiooya, Machidashi, Tokyo 194, Japan

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First published: July 05, 1993

https://doi.org/10.1016/0014-5793(93)81066-9

Citations: 321

Correspondence address: K. Ishiguro, Mitsubishi Kasei Institute of Life Sciences, 11 Minamiooya, Machidashi, Tokyo 194, Japan. Fax: (81) (427) 291 259.

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Abstract

We previously reported that tau protein kinase I (TPKI) induced normal tau protein into a state of paired helical filaments (PHF); this is further confirmed here by immunoblot analysis using several antibodies. We also present the amino acid sequence of TPKI, which is identical to glycogen synthase kinase 3β (GSK3β). Moreover, we found that TPKI activity was inseparable from GSK3 activity throughout the purification procedure. These results indicate that TPKI is identical to GSK3β.

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Volume325, Issue3

July 05, 1993

Pages 167-172

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