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Volume 275, Issue 1-2 p. 1-5
Review letter
Free Access

Active transport of proteins into the nucleus

Philipp Wagner

Philipp Wagner

Department of Biochemistry, Biocenter of the University of Basel, CH-4056 Basel, Switzerland

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Jeannette Kunz

Jeannette Kunz

Department of Biochemistry, Biocenter of the University of Basel, CH-4056 Basel, Switzerland

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Antonius Koller

Antonius Koller

Department of Biochemistry, Biocenter of the University of Basel, CH-4056 Basel, Switzerland

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Michael N. Hall

Corresponding Author

Michael N. Hall

Department of Biochemistry, Biocenter of the University of Basel, CH-4056 Basel, Switzerland

Correspondence address: M.N. Hall, Department of Biochemistry, Biocenter of the University of Basel CH-4056 Basel, SwitzerlandSearch for more papers by this author
First published: November 26, 1990
Citations: 18

Abstract

Nuclear proteins are actively and posttranslationally transported across the nuclear envelope. This transport is highly selective process that can be divided into two steps, receptor-binding followed by translocation through the nuclear envelope. Receptor-binding is mediated by nuclear localization signals that have been identified in many nuclear proteins. Translocation is energy-dependent and occurs through the nuclear pore complex.