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Volume 259, Issue 1 p. 199-201
Research letters
Free Access

Secretion of islet amyloid polypeptide in response to glucose

A. Kanatsuka

Corresponding Author

A. Kanatsuka

Second Department of Internal Medicine, Chiba University School of Medicine, Chiba 280, Japan

Correspondence address: A. Kanatsuka, Second Department of Internal Medicine, Chiba University School of Medicine, 1-8-1 Inohana, Chiba 28, Japan.Search for more papers by this author
H. Makino

H. Makino

Second Department of Internal Medicine, Chiba University School of Medicine, Chiba 280, Japan

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H. Ohsawa

H. Ohsawa

Second Department of Internal Medicine, Chiba University School of Medicine, Chiba 280, Japan

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Y. Tokuyama

Y. Tokuyama

Second Department of Internal Medicine, Chiba University School of Medicine, Chiba 280, Japan

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T. Yamaguchi

T. Yamaguchi

Second Department of Internal Medicine, Chiba University School of Medicine, Chiba 280, Japan

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S. Yoshida

S. Yoshida

Second Department of Internal Medicine, Chiba University School of Medicine, Chiba 280, Japan

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M. Adachi

M. Adachi

Japan Immunoresearch Laboratories, Takasaki 370, Japan

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First published: December 18, 1989
Citations: 82

Abstract

The content of isolet amyloid polypeptide (IAPP) in isolated rat pancreatic islets was determined by a radioimmunoassay. Reverse-phase high-performance liquid chromatography analysis revealed that a main peak of IAPP immunoreactivity in the extracts from the islets corresponded to a synthetic rat IAPP. Secretion of IAPP from the cells is regulated by the extracellular glucose concentration. Thus, IAPP may be a novel regulator for glucose homeostasis and changes in the secretion perhaps relate to insular amyloid deposits and impaired glucose tolerance in type 2 diabetes mellitus.