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Volume 231, Issue 2 p. 440-444
Full-length article
Free Access

Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium-derived vasoconstrictor peptide, endothelin: Identity of human and porcine endothelin

Yasuaki Itoh

Corresponding Author

Yasuaki Itoh

Tsukuba Research Laboratories, Takeda Chemical Industries, Ltd, Wadai, Tsukuba, Ibaraki 305, Japan

Y. Itoh, Tsukuba Research Laboratories, Takeda Chemical Industries, Ltd, Wadai, Tsukuba, Ibaraki 305, JapanSearch for more papers by this author
Masashi Yanagisawa

Masashi Yanagisawa

Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305, Japan

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Shoichi Ohkubo

Shoichi Ohkubo

Tsukuba Research Laboratories, Takeda Chemical Industries, Ltd, Wadai, Tsukuba, Ibaraki 305, Japan

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Chiharu Kimura

Chiharu Kimura

Tsukuba Research Laboratories, Takeda Chemical Industries, Ltd, Wadai, Tsukuba, Ibaraki 305, Japan

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Takuo Kosaka

Takuo Kosaka

Tsukuba Research Laboratories, Takeda Chemical Industries, Ltd, Wadai, Tsukuba, Ibaraki 305, Japan

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Akihiro Inoue

Akihiro Inoue

Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305, Japan

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Norio Ishida

Norio Ishida

Fermentation Research Institute, Agency of Industrial Science and Technology, Tsukuba, Ibaraki 305, Japan

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Youji Mitsui

Youji Mitsui

Fermentation Research Institute, Agency of Industrial Science and Technology, Tsukuba, Ibaraki 305, Japan

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Haruo Onda

Haruo Onda

Tsukuba Research Laboratories, Takeda Chemical Industries, Ltd, Wadai, Tsukuba, Ibaraki 305, Japan

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Masahiko Fujino

Masahiko Fujino

Tsukuba Research Laboratories, Takeda Chemical Industries, Ltd, Wadai, Tsukuba, Ibaraki 305, Japan

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Tomoh Masaki

Tomoh Masaki

Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305, Japan

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First published: April 25, 1988
Citations: 307

Abstract

A cDNA encoding a human endothelium-derived vasoconstrictor peptide, endothelin, was isolated from a human placenta cDNA library. The nucleotide sequence of this cDNA clone showed that the primary structure of the human preproendothelin has 212 amino acid residues and is highly homologous to porcine preproendothelin, and that human endothelin is identical with porcine endothelin.