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Volume 204, Issue 2 p. 288-292
Research letters
Free Access

Cyclic GMP phosphodiesterase from cattle retina

Amino acid sequence of the γ-subunit and nucleotide sequence of the corresponding cDNA

Yu.A. Ovchinnikov

Yu.A. Ovchinnikov

Shemyakin Institute of Bioorganic Chemistry, USSR Academy of Sciences, ul. Miklukho-Maklaya, 16/10, 117871 GSP Moscow V-437, USSR

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V.M. Lipkin

V.M. Lipkin

Shemyakin Institute of Bioorganic Chemistry, USSR Academy of Sciences, ul. Miklukho-Maklaya, 16/10, 117871 GSP Moscow V-437, USSR

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V.P. Kumarev

V.P. Kumarev

Shemyakin Institute of Bioorganic Chemistry, USSR Academy of Sciences, ul. Miklukho-Maklaya, 16/10, 117871 GSP Moscow V-437, USSR

Present address: Institute of Cytology and Genetics, Siberian Branch of the Academy of Sciences of the USSR, Novosibirsk, USSR. Search for more papers by this author
V.V. Gubanov

V.V. Gubanov

Shemyakin Institute of Bioorganic Chemistry, USSR Academy of Sciences, ul. Miklukho-Maklaya, 16/10, 117871 GSP Moscow V-437, USSR

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N.V. Khramtsov

N.V. Khramtsov

Shemyakin Institute of Bioorganic Chemistry, USSR Academy of Sciences, ul. Miklukho-Maklaya, 16/10, 117871 GSP Moscow V-437, USSR

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N.B. Akhmedov

N.B. Akhmedov

Shemyakin Institute of Bioorganic Chemistry, USSR Academy of Sciences, ul. Miklukho-Maklaya, 16/10, 117871 GSP Moscow V-437, USSR

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V.E. Gubanov

V.E. Gubanov

Shemyakin Institute of Bioorganic Chemistry, USSR Academy of Sciences, ul. Miklukho-Maklaya, 16/10, 117871 GSP Moscow V-437, USSR

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K.G. Muradov

K.G. Muradov

Shemyakin Institute of Bioorganic Chemistry, USSR Academy of Sciences, ul. Miklukho-Maklaya, 16/10, 117871 GSP Moscow V-437, USSR

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First published: August 18, 1986
Citations: 92

Abstract

The primary structure of the γ-subunit of cyclic GMP phosphodiesterase was determined by parallel analysis of the amino acid sequence of the protein and nucleotide sequence of the corresponding cDNA. The enzyme γ-subunit contains 87 amino acid residues, its N-terminal amino group being acetylated.