FEBS Letters Award
The FEBS Letters Award 2016
Every other year, FEBS Letters offers a prestigious prize of €10,000 to the senior author of an outstanding Research Letter published in FEBS Letters during the previous two calendar years. The criteria for this selection are based on functional insight, depth of experimental analysis and broadness of impact.
FEBS Letters is happy to announce that the FEBS Letters Award 2016 will be presented jointly to Kim Nasmyth (University of Oxford, UK) and Jan Löwe (MRC, Cambridge, UK) for their outstanding paper:
Maurici B. Roig, Jan Löwe, Kok-Lung Chan, Frédéric Beckouët, Jean Metson and Kim Nasmyth
Sister chromatids are held together by the cohesin ring structure, which is created through association of a kleisin subunit (Scc1/Rad21) with ATPase heads of Smc1/Smc3 heterodimers. Scc3 is the most important of cohesin’s regulatory subunits. Nasmyth/Löwe and colleagues have now solved the crystal structure of the yeast Scc3 subunit, analyzed its interaction with Scc1 and determined the key residues for cohesin’s release from chromatin. Using live-cell studies they suggest that Scc3 can turn over more rapidly than the 'core' cohesin subunits, and is responsible for maintaining as well as establishing cohesion. Scc3 turns over in G2/M while maintaining cohesin’s association with chromosomes and it promotes de-acetylation of Smc3 upon Scc1 cleavage. These findings are expected to provide insight into a broad range of molecular events related to chromatin organization and regulation.
The winning article is selected by a special Award Committee, formed by appointed members of the Editorial Board, plus one external member. The Award Committee members were: Laszlo Nagy (Orlando) Chair, Miguel De la Rosa (Seville), Irene Diaz Moreno (Seville), Wilfried Ellmeier (Vienna), and Daniela Ruffell (Editorial Office).
Dr Jan Löwe will give a plenary lecture about his work at the FEBS Congress in Ephesus/Kuşadası (Turkey) in September 2016, where he will be officially presented with the prize, on behalf of both winners.
Past Award Winners
- The 2016 FEBS Letters Crossword Challenge now solved!
Please click on the link above to access The FEBS Letters Crossword with clues based on the 2016 Editors’ Choices, and scroll down for the solutions.
- We congratulate FEBS Letters author Prof. Yoshinori Ohsumi on winning the 2016 Nobel Prize in Physiology or Medicine
- Read the celebratory FEBS Letters Virtual Issue "Autophagy: The 2016 Nobel Prize" collecting elegant studies on autophagy performed by Yoshinori Ohsumi and his coworkers