2016 Nobel Prize in Physiology or Medicine to Yoshinori Ohsumi
Seminal Work on Autophagy Published in FEBS Letters
We congratulate Prof. Yoshinori Ohsumi on winning the 2016 Nobel Prize in Physiology or Medicine for his groundbreaking research on the molecular mechanisms underlying autophagy in yeast. In an outstanding FEBS Letters article from 1993, Ohsumi isolated 15 mutants with defective accumulation of autophagic bodies under conditions of starvation. The mutants indicated that at least 15 independent genes encoded components of the autophagic machinery in yeast. Following this pioneering study, the proteins encoded by these genes were functionally characterized. Autophagy is now known to be a very important physiological process involved in the cellular response to stress and infection, and to play a role in development and aging. Defects in the autophagic pathway have been linked to cancer, Parkinson’s disease and diabetes as well as other genetic diseases.
FEBS Letters is proud to have had the honor of publishing this as well as many other excellent articles by Prof Ohsumi, and to have contributed to the dissemination of Nobel Prize-worthy science.
To celebrate the occasion, we have created the Virtual Issue “Autophagy: The 2016 Nobel Prize” collecting elegant studies on autophagy performed by Yoshinori Ohsumi and his coworkers, that were published in FEBS Letters.