FEBS Press is pleased to welcome its fourth journal, Molecular Oncology, to this platform. Molecular Oncology is now fully Open Access and all content from the past 10 years is now available for all to read. The publication of high-quality journals by scientists for scientists is one the core objectives of The Federation of European Biochemical Societies (FEBS), with the revenue raised supporting fellowships, courses, congresses and other activities.

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The FEBS Journal For high-quality full-length papers and reviews, with particular focus on biochemistry, molecular biology, structural biology and cell biology.
FEBS Letters For highly significant research letters that merit urgent publication, as well as timely reviews of wide interest in the molecular biosciences.
Molecular OncologyFor high-impact discoveries, approaches and technical advances in basic, clinical and discovery-driven translational cancer research.
FEBS Open Bio For rapid open access publication of scientifically sound research articles in the molecular and cellular life sciences.

Highlighted Articles

Chakraborty and Ghosh

The epsilon motif of hepatitis B virus RNA exhibits a potassium-dependent ribonucleolytic activity

Chakraborty and Ghosh, The FEBS Journal

Transcription of the hepatitis B virus (HBV) DNA produces a pregenomic RNA which folds into an epsilon loop element that is essential for viral replication. Chakraborty and Ghosh now show that this epsilon motif contains a ribozyme activity which depends on potassium ions and can act in trans, cleaving other RNAs. This study highlights a new class of ribozyme, raising interesting questions about the functions of the epsilon motif in the hepatitis B virus life cycle.

Chen and Chou

Structure of the transmembrane domain of HIV-1 envelope glycoprotein

Chen and Chou , The FEBS Journal

The HIV-1 envelope spike is a type 1 membrane protein that fuses the viral and host cell membranes and thus mediates viral entry and infection. Chen and Chou recently reported the structure of the transmembrane (TM) domain of HIV-1 envelop reconstituted in a membrane-like environment. In this Structural Snapshot, they discuss how the TM domain anchors, stabilises and modulates a viral envelope spike and how this high-resolution structure can contribute to vaccine development.

Liu F. and colleagues

C-terminal truncation of GSK-3β enhances its dephosphorylation by PP2A

Liu F. and colleagues, FEBS Letters

Microtubule-associated protein tau is a substrate of glycogen synthase kinase 3β (GSK-3β), and tau hyperphosphorylation is a hallmark of neurodegenerative diseases. This study clarifies the link between the presence of truncated GSK-3β in the brain of patients with Alzheimer’s disease and tau hyperphosphorylation. C-terminal GSK-3β truncation promotes GSK-3β nuclear localization and interaction with the PP2A phosphatase, which is known to maintain GSK-3β kinase activity.

Assfalg, M. and colleagues

Identification of primary and secondary UBA footprints on the surface of ubiquitin in cell-mimicking crowded solution

Assfalg, M. and colleagues, FEBS Letters

Interactions between ubiquitin (Ub) and divers proteins with Ub-binding domains (UBDs) regulate many cellular processes. Here, using a polymeric Ficoll solution and NMR, the authors investigate how Ub-UBD interactions are influenced by macromolecular crowding in the intracellular milieu. The study provides insights into weak secondary interactions and protein-protein interaction dynamics within the cell.

Obayashi and colleagues

Multiple expression cassette exchange via TP901-1, R4 and Bxb1 integrase systems on a mouse artificial chromosome

Obayashi and colleagues, FEBS Open Bio

Here, Obayashi and colleagues created a reporter system to evaluate the precise target DNA excision for TP901-1, R4 and Bxb1 integrases, utilised in lineage tracing. In response to transient expression of specific integrases in hamster ovary cells, luciferase expression was exchanged for fluorescent protein expression – 3 distinct luciferases and 3 fluorescent proteins created up to 8 expression patterns. This reporter system was inserted into a mouse artificial chromosome vector. The multiple expression cassette exchange via site-speciļ¬c recombinases (MEEVS) platform explicated here could lead to complex genomic manipulations, not solely in tissue culture cells but in animals, yeast and plants - using combinations of SSRs, artificial chromosomes and other genome editing tools.

Brat and colleagues

TRIM8 regulates stemness in glioblastoma through PIAS3-STAT3

Brat and colleagues, Molecular Oncology

Glioblastoma (GBM) is the most malignant form of primary brain tumour, with a median survival of 12–15 months following standard therapy. GBM stem-like cells (GSCs) contribute to the rapid growth, therapeutic resistance and clinical recurrence of these fatal tumours. Brat and colleagues report that tri-partite motif-containing protein 8 (TRIM8) activates STAT3 signalling via the suppression of protein inhibitor of STAT3 (PIAS3) expression to perpetuate stemness and the self-renewing capabilities of GSCs. Targeting TRIM8 reduced GSC stem cell marker expression and self-renewal capacity, suggesting that TRIM8 and STAT3 signalling pathways are potential therapeutic targets for GBM.

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