FEBS Press is pleased to welcome its fourth journal, Molecular Oncology, to this platform. Molecular Oncology is now fully Open Access and all content from the past 10 years is now available for all to read. The publication of high-quality journals by scientists for scientists is one the core objectives of The Federation of European Biochemical Societies (FEBS), with the revenue raised supporting fellowships, courses, congresses and other activities.
Chakraborty and Ghosh, The FEBS Journal
Transcription of the hepatitis B virus (HBV) DNA produces a pregenomic RNA which folds into an epsilon loop element that is essential for viral replication. Chakraborty and Ghosh now show that this epsilon motif contains a ribozyme activity which depends on potassium ions and can act in trans, cleaving other RNAs. This study highlights a new class of ribozyme, raising interesting questions about the functions of the epsilon motif in the hepatitis B virus life cycle.
Chen and Chou , The FEBS Journal
The HIV-1 envelope spike is a type 1 membrane protein that fuses the viral and host cell membranes and thus mediates viral entry and infection. Chen and Chou recently reported the structure of the transmembrane (TM) domain of HIV-1 envelop reconstituted in a membrane-like environment. In this Structural Snapshot, they discuss how the TM domain anchors, stabilises and modulates a viral envelope spike and how this high-resolution structure can contribute to vaccine development.
Liu F. and colleagues, FEBS Letters
Microtubule-associated protein tau is a substrate of glycogen synthase kinase 3β (GSK-3β), and tau hyperphosphorylation is a hallmark of neurodegenerative diseases. This study clarifies the link between the presence of truncated GSK-3β in the brain of patients with Alzheimer’s disease and tau hyperphosphorylation. C-terminal GSK-3β truncation promotes GSK-3β nuclear localization and interaction with the PP2A phosphatase, which is known to maintain GSK-3β kinase activity.
Identification of primary and secondary UBA footprints on the surface of ubiquitin in cell-mimicking crowded solution
Assfalg, M. and colleagues, FEBS Letters
Interactions between ubiquitin (Ub) and divers proteins with Ub-binding domains (UBDs) regulate many cellular processes. Here, using a polymeric Ficoll solution and NMR, the authors investigate how Ub-UBD interactions are influenced by macromolecular crowding in the intracellular milieu. The study provides insights into weak secondary interactions and protein-protein interaction dynamics within the cell.
Multiple expression cassette exchange via TP901-1, R4 and Bxb1 integrase systems on a mouse artificial chromosome
Obayashi and colleagues, FEBS Open Bio
Here, Obayashi and colleagues created a reporter system to evaluate the precise target DNA excision for TP901-1, R4 and Bxb1 integrases, utilised in lineage tracing. In response to transient expression of specific integrases in hamster ovary cells, luciferase expression was exchanged for fluorescent protein expression – 3 distinct luciferases and 3 fluorescent proteins created up to 8 expression patterns. This reporter system was inserted into a mouse artificial chromosome vector. The multiple expression cassette exchange via site-speciﬁc recombinases (MEEVS) platform explicated here could lead to complex genomic manipulations, not solely in tissue culture cells but in animals, yeast and plants - using combinations of SSRs, artificial chromosomes and other genome editing tools.
Brat and colleagues, Molecular Oncology
Glioblastoma (GBM) is the most malignant form of primary brain tumour, with a median survival of 12–15 months following standard therapy. GBM stem-like cells (GSCs) contribute to the rapid growth, therapeutic resistance and clinical recurrence of these fatal tumours. Brat and colleagues report that tri-partite motif-containing protein 8 (TRIM8) activates STAT3 signalling via the suppression of protein inhibitor of STAT3 (PIAS3) expression to perpetuate stemness and the self-renewing capabilities of GSCs. Targeting TRIM8 reduced GSC stem cell marker expression and self-renewal capacity, suggesting that TRIM8 and STAT3 signalling pathways are potential therapeutic targets for GBM.
About FEBS Press
News about FEBS Press
Cancer biology, Microbiology, Plant Biology, and Computational and Systems Biology
- We congratulate FEBS Letters author Prof. Yoshinori Ohsumi on winning the 2016 Nobel Prize in Physiology or Medicine
News about FEBS
IUBMB–FEBS conference: New Horizons in Biochemistry and Molecular Biology Education
An event devoted to advancing teaching and learning in the molecular life sciences...
More FEBS Advanced Courses 2017
There's still time to register for courses on topics from biomembranes to immunology...
FEBS bursaries to assist FEBS 2017 participation
Check out the FEBS bursary scheme for early-career scientists presenting work at the FEBS Congress...
Second call for 2018 FEBS Advanced Courses proposals: apply by 1 July
Expert scientists: advance your research field by organizing a FEBS-funded event!...
FEBS Summer Fellowships 2017
Support for pre-doctoral students for research in a different country: apply by April 1st...