FEBS Press is pleased to welcome its fourth journal, Molecular Oncology, to this platform. Molecular Oncology will become fully Open Access from 2017 and authors wishing to submit a paper, can do so here. The publication of high-quality journals by scientists for scientists is one the core objectives of The Federation of European Biochemical Societies (FEBS), with the revenue raised supporting fellowships, courses, congresses and other activities.
Beneficial effects of increased lysozyme levels in Alzheimer's disease modelled in Drosophila melanogaster
Brorsson, Kågedal and colleagues, The FEBS Journal
A connection between amyloid β (Aβ) pathology and lysozyme expression in Alzheimer’s disease has recently been observed in patient samples and transgenic animal models, but its implications are still poorly understood. Brorsson, Kågedal and colleagues found that expression of lysozyme in transgenic Alzheimer’s Disease Drosophila models rescued disease phenotype and increased fly survival, which indicate that targeting lysozyme may represent a new treatment strategy.
Directly targeting the mitochondrial pathway of apoptosis for cancer therapy using BH3 mimetics - recent successes, current challenges and future promise
Kristopher Sarosiek and Anthony Letai, The FEBS Journal
To survive, many cancer cells upregulate and ultimately become reliant on anti-apoptotic proteins such as BCL-2. Inhibiting BCL-2 with the use of BH3 mimetics, therefore, represents a promising strategy for cancer therapy, as discussed by Sarosiek and Letai in this State-of-the-Art review.
Andreas S. Reichert and colleagues, FEBS Letters
OPA1 has been previously attributed an antiapoptotic activity. However, the present study shows that stable OPA1 knockdown confers resistance to apoptosis. The levels of OPA1 reversely correlated with those of MIC60, which is required for cristae junction (CJ) formation and regulates cytochrome c release from the mitochondria. Although OPA1 was dispensable for CJ formation, the authors propose that OPA1-mediated regulation of MIC60 may be involved in the resistance of OPA1-deficient cells to apoptosis.
Mohamed A. Marahiel and colleagues, FEBS Letters
Lasso peptides are a class of ribosomally synthesized and post-translationally modified peptides with an unusual lariat knot-like structure. Marahiel and colleagues have recently identified lasso peptide-tailoring kinases that specifically phosphorylate the precursor of lasso peptides. Now, they show that such kinases can polyphosphorylate lasso peptide precursors in a substrate sequence-dependent manner, leading to a previously unappreciated diversity of lasso peptide forms.
Efficient generation of selection-gene-free rat knockout models by homologous recombination in ES cells
Sen Wu and colleagues, FEBS Letters
Herein, Lan et al. report an optimized and efficient strategy for gene knockout in rats adopting the ACN self-excision cassette used in mouse gene targeting. Applying this strategy, the authors successfully engineer rat embryonic stem cells to generate Leptin and p53 knockout rats. Self-excision of the ACN cassette leads to removal of the selection genes in the transgenic rats—an added highlight of the technique.
FEBS Press News
- We congratulate FEBS Letters author Prof. Yoshinori Ohsumi on winning the 2016 Nobel Prize in Physiology or Medicine
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