FEBS Press is pleased to welcome its fourth journal, Molecular Oncology, to this platform. Molecular Oncology is now fully Open Access and all content from the past 10 years is now available for all to read. The publication of high-quality journals by scientists for scientists is one the core objectives of The Federation of European Biochemical Societies (FEBS), with the revenue raised supporting fellowships, courses, congresses and other activities.
Wu and colleagues, The FEBS Journal
Circular RNAs are endogenous non‐coding RNAs that regulate gene expression and have been linked to the development and progression of cancer. Guoqiu Wu and colleagues now report that the circular RNA hsa_circ_0013958 is a potential biomarker for lung adenocarcinoma. Furthermore, has_circ_0013958 induces cell proliferation and invasion and inhibits apoptosis in vitro, potentially by acting as a sponge for miR‐134, which has previously been reported to suppress the development of non‐small‐cell lung carcinoma.
Francia, d’Adda di Fagagna and colleagues, The FEBS Journal
The generation of DNA double‐strand breaks (DSBs) within actively transcribed regions elicits a complex transcriptional response in cis to the lesion, which favours DSB repair. This causes both transcriptional repression of damaged genes and the biogenesis of DSB‐induced small noncoding RNAs. In this State-of-the-Art Review, Francia, d’Adda di Fagagna and colleagues discuss the modulation of transcription at DSBs and its tight connection with the activation of the DNA damage response.
Fujita H. and colleagues, FEBS Letters
Non-receptor tyrosine kinase Src has a central role in mechanotransduction at focal adhesions. According to the prevailing model, inactive cytosolic Src translocates to the cell membrane following N-myristoylation; once activated at the cell membrane, Src transitions to focal adhesions. Using an N-myristoylation-defective mutant, the authors show that cytosolic Src can directly translocate to and be activated at focal adhesions through an alternative pathway.
Shi, YQ and colleagues, FEBS Letters
Hepatocyte nuclear factor 1α (HNF1α) controls, among others, lipid and glucose metabolism. Hepatocyte-specific deletion of HNF1α in mice led to a fatty liver phenotype that further developed into non-alcoholic liver steatohepatitis (NASH) and spontaneous hepatocellular carcinoma (HCC). The authors argue that this new mouse model is distinct from HCC models based on chemical reagents, and provides a suitable tool for the study of NASH–HCC.
The neuronal and astrocytic protein SLC38A10 transports glutamine, glutamate, and aspartate, suggesting a role in neurotransmission
Hellsten and colleagues, FEBS Open Bio
Within brain cells, glutamine transporters are essential for the monitoring and control of glutamate and GABA levels. Here, Hellsten and colleagues report the first histological and functional characterisation of SLC38A10, a previous orphan member of the SLC38 family of amino acid transporters. SLC38A10 immunostaining was abundant in the mouse brain, showing colocalised staining with markers for neurons and astrocytes. Transport assays suggest the transporter is bidirectional and can mediate uptake and efflux of multiple neurotransmitters. Together, these studies suggest that SLC38A10 may potentially play a role in excitatory and inhibitory neurotransmission.
Epithelial/mesenchymal plasticity: how have quantitative mathematical models helped improve our understanding?
Levine and colleagues, Molecular Oncology
Epithelial-to-mesenchymal transition (EMT) and mesenchymal-to-epithelial transition (MET) are thought to be fundamental in the metastatic dissemination of carcinomas. EMT and MET are not discrete states, with carcinoma cells frequently exhibiting a spectrum of epithelial/mesenchymal phenotypes. Currently, whether epithelial/mesenchymal plasticity is requisite for metastatic dissemination remains unknown. Here, Levine et al. focus on epithelial/mesenchymal plasticity and its role in metastatic outgrowth, suggesting alternative mechanisms that may underpin successful dissemination beyond the classic EMT/MET view. The authors highlight several hypotheses that may attune conflicting observations, and put forward a framework of key questions that may offer valuable insight into the metastatic mechanisms in multiple tumour models.
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- We congratulate FEBS Letters author Prof. Yoshinori Ohsumi on winning the 2016 Nobel Prize in Physiology or Medicine
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