FEBS Press is pleased to welcome its fourth journal, Molecular Oncology, to this platform. Molecular Oncology is now fully Open Access and all content from the past 10 years is now available for all to read. The publication of high-quality journals by scientists for scientists is one the core objectives of The Federation of European Biochemical Societies (FEBS), with the revenue raised supporting fellowships, courses, congresses and other activities.
The FEBS Journal
The FEBS Journal Special Issue on Proteases and Proteolysis in Health and Disease is out! Eleven specially commissioned reviews from experts in the field cover important and emerging topics in this diverse field, from protease deregulation in disease and protease-targeting drug development, to the latest methodologies in measuring protease activity. We are grateful to our authors for their contributions and hope you enjoy reading these reviews as much as we have!
Sciacovelli and Frezza, The FEBS Journal
Epithelial-to-mesenchymal transition (EMT) is a process whereby epithelial cancer cells acquire mesenchymal features that enable invasion and metastasis. This transformative process is associated with complex metabolic reprogramming. In this State-of-the-Art Review, Sciacovelli and Frezza highlight the underpinnings of metabolic rewiring during EMT and the interconnectivity between the metabolism and EMT activation.
Dewilde S. and colleagues, FEBS Letters
Neuroglobin (Ngb) and Cytoglobin (Cygb) may confer neuroprotection through their ROS-scavenging activity. In late-stage Alzheimer’s disease (AD), Ngb expression in the brain is downregulated. Here, using a mouse model of AD, the authors investigate whether whole body hypoxia as a secondary insult may downregulate globin expression in the brain through a mechanism involving the transcription factor REST.
Serrano, M.A. and colleagues, FEBS Letters
Guëll et al. determine reaction fluxes in the metabolic network of E. coli using Flux Balance Analysis. Applying a disparity filter to preserve the complexity of the original network, the authors extract the Significant Flux Backbone (SFB), which reveals fingerprints of evolution and environmental adaptation.
Multiple expression cassette exchange via TP901-1, R4 and Bxb1 integrase systems on a mouse artificial chromosome
Obayashi and colleagues, FEBS Open Bio
Here, Obayashi and colleagues created a reporter system to evaluate the precise target DNA excision for TP901-1, R4 and Bxb1 integrases, utilised in lineage tracing. In response to transient expression of specific integrases in hamster ovary cells, luciferase expression was exchanged for fluorescent protein expression – 3 distinct luciferases and 3 fluorescent proteins created up to 8 expression patterns. This reporter system was inserted into a mouse artificial chromosome vector. The multiple expression cassette exchange via site-speciﬁc recombinases (MEEVS) platform explicated here could lead to complex genomic manipulations, not solely in tissue culture cells but in animals, yeast and plants - using combinations of SSRs, artificial chromosomes and other genome editing tools.
ZKSCAN1 gene and its related circular RNA (circZKSCAN1) both inhibit hepatocellular carcinoma cell growth, migration, and invasion but through different signaling pathways
Liu and colleagues, Molecular Oncology
There is increasing evidence to suggest that circular RNA (circRNA) are involved in cancer development, yet the regulation and function of human circRNA remains elusive. Here, Liu and colleagues demonstrate the linear and circular expression of ZKSCAN1, a zinc family gene, in human hepatocellular carcinoma (HCC) tissues and cell lines. Results reveal two post-translational products that cooperate via different pathways to inhibit growth, migration and invasion of HCC, with the suggestion that cirZKSCAN1 may prove to be a useful marker in HCC.
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- We congratulate FEBS Letters author Prof. Yoshinori Ohsumi on winning the 2016 Nobel Prize in Physiology or Medicine
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