FEBS Press is pleased to welcome its fourth journal, Molecular Oncology, to this platform. Molecular Oncology will become fully Open Access from 2017 and authors wishing to submit a paper, can do so here. The publication of high-quality journals by scientists for scientists is one the core objectives of The Federation of European Biochemical Societies (FEBS), with the revenue raised supporting fellowships, courses, congresses and other activities.
Jesús de la Cruz and colleagues (2016), The FEBS Journal
Ribosomal biogenesis is a highly coordinated process involving a large number of proteins. Using the yeast genetics toolset, de la Cruz and colleagues provide molecular details on the essential role of the ribosomal protein L16 in the assembly of the 60S subunit. This study also consolidates previous major findings involving the mammalian orthologue of yeast L16 protein.
Hardie and colleagues (2016), The FEBS Journal
The AMP-activated protein kinase (AMPK) is a central energy sensor found in all eukaryotes as a trimeric complex. In this State-of-the-Art Review, Hardie and colleagues present a comprehensive overview of the structural features of the AMPK isoforms, their evolutionary origins and functional regulation and discuss emerging roles in cancer development.
Philip D. Laible and colleagues, FEBS Letters
During photosynthesis light is converted into chemical energy at reaction centers (RCs). RCs consist of a transmembrane complex combined with cofactors that are arranged symmetrically across two paths of electron transfer (ET) — the A-side and the B-side ET pathways. In type II RCs (typical of purple bacteria), the A-side ET pathway is active, whereas the B-side ET pathway is suppressed. Here, the authors employ a new high-throughput approach to generate structural RC variants, and reveal that the B-side ET pathways of the highly homologous RCs of two Rhodobacter species are likely to be suppressed through distinct mechanisms.
Direct protein–protein interactions and substrate channeling between cellular retinoic acid binding proteins and CYP26B1
Nina Isoherranen and colleagues, FEBS Letters
All-trans-retinoic acid (atRA), the main active metabolite of vitamin A, is known to bind to the soluble cytosolic carrier proteins CRAB-I and CRAB-II. This study indicates that CRAB-I and CRAB-II deliver the atRA substrate to the ER-resident atRA-catabolizing enzyme CYP26B1. The authors speculate that other fat-soluble substrates may also be delivered for catabolism to cytochrome P450 (CYP) enzymes by soluble cytosolic carrier proteins.
Traumatic brain injury increases levels of miR-21 in extracellular vesicles: implications for neuroinflammation
Sowmya Yelamanchili and colleagues, FEBS Open Bio
Effective treatment strategies for traumatic brain injury (TBI) remain elusive. Cell–cell communication is critical in TBI and extracellular vesicles (EVs) are known to carry cargo between cells. Harrison and colleagues found that TBI induced global changes in the miRNA content of brain‐derived EVs, with miR‐21 showing the largest increase. Expression of miR-21 was primarily localized to neurons near the lesion site. These findings indicate that miR‐21 may play a crucial role in cell–cell communication after brain injury.
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The FEBS 2016 Congress is cancelled
The FEBS Executive Committee are very sorry to announce that the FEBS Congress in Kuşadasi from 3rd to 8th September is cancelled...
The July 2016 issue of FEBS News is out!
From fellowships to events to journals – enjoy a snapshot of current FEBS activities ...
FEBS Fellowships call 2016 is now open
Apply before 1 October 2016 for FEBS Long-Term and Return-to-Europe Fellowships...
Upcoming FEBS Workshops 2016
Apply now for workshops on Coenzyme A and on Chromatin proteomics...