FEBS Press is pleased to welcome its fourth journal, Molecular Oncology, to this platform. Molecular Oncology will become fully Open Access from 2017 and authors wishing to submit a paper, can do so here. The publication of high-quality journals by scientists for scientists is one the core objectives of The Federation of European Biochemical Societies (FEBS), with the revenue raised supporting fellowships, courses, congresses and other activities.

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The FEBS Journal For high-quality full-length papers and reviews, with particular focus on biochemistry, molecular biology, structural biology and cell biology.
FEBS Letters For highly significant research letters that merit urgent publication, as well as timely reviews of wide interest in the molecular biosciences.
Molecular OncologyFor high-impact discoveries, approaches and technical advances in basic, clinical and discovery-driven translational cancer research.
FEBS Open Bio For rapid open access publication of scientifically sound research articles in the molecular and cellular life sciences.

Highlighted Articles

brorsson and kegedal

Beneficial effects of increased lysozyme levels in Alzheimer's disease modelled in Drosophila melanogaster

Brorsson, Kågedal and colleagues, The FEBS Journal

A connection between amyloid β (Aβ) pathology and lysozyme expression in Alzheimer’s disease has recently been observed in patient samples and transgenic animal models, but its implications are still poorly understood. Brorsson, Kågedal and colleagues found that expression of lysozyme in transgenic Alzheimer’s Disease Drosophila models rescued disease phenotype and increased fly survival, which indicate that targeting lysozyme may represent a new treatment strategy.

Sarosiek and Letai

Directly targeting the mitochondrial pathway of apoptosis for cancer therapy using BH3 mimetics - recent successes, current challenges and future promise

Kristopher Sarosiek and Anthony Letai, The FEBS Journal

To survive, many cancer cells upregulate and ultimately become reliant on anti-apoptotic proteins such as BCL-2. Inhibiting BCL-2 with the use of BH3 mimetics, therefore, represents a promising strategy for cancer therapy, as discussed by Sarosiek and Letai in this State-of-the-Art review.

OPA1 functionally highlight

OPA1 functionally interacts with MIC60 but is dispensable for crista junction formation

Andreas S. Reichert and colleagues, FEBS Letters

OPA1 has been previously attributed an antiapoptotic activity. However, the present study shows that stable OPA1 knockdown confers resistance to apoptosis. The levels of OPA1 reversely correlated with those of MIC60, which is required for cristae junction (CJ) formation and regulates cytochrome c release from the mitochondria. Although OPA1 was dispensable for CJ formation, the authors propose that OPA1-mediated regulation of MIC60 may be involved in the resistance of OPA1-deficient cells to apoptosis.

Dual substrate-controlled kinase highlight

Dual substrate-controlled kinase activity leads to polyphosphorylated lasso peptides

Mohamed A. Marahiel and colleagues, FEBS Letters

Lasso peptides are a class of ribosomally synthesized and post-translationally modified peptides with an unusual lariat knot-like structure. Marahiel and colleagues have recently identified lasso peptide-tailoring kinases that specifically phosphorylate the precursor of lasso peptides. Now, they show that such kinases can polyphosphorylate lasso peptide precursors in a substrate sequence-dependent manner, leading to a previously unappreciated diversity of lasso peptide forms.

Efficient generation highlight

Efficient generation of selection-gene-free rat knockout models by homologous recombination in ES cells

Sen Wu and colleagues, FEBS Letters

Herein, Lan et al. report an optimized and efficient strategy for gene knockout in rats adopting the ACN self-excision cassette used in mouse gene targeting. Applying this strategy, the authors successfully engineer rat embryonic stem cells to generate Leptin and p53 knockout rats. Self-excision of the ACN cassette leads to removal of the selection genes in the transgenic rats—an added highlight of the technique.

FEBS Press News

NobelRead the celebratory FEBS Letters Virtual Issue "Autophagy: The 2016 Nobel Prize" collecting studies by Yoshinori Ohsumi and his coworkers

Click the below button to submit your Open Access paper!

This Virtual Issue showcases specially selected articles from the FEBS Press journals – The FEBS Journal, FEBS Letters and FEBS Open Bio - published in 2016

FEBS Press is delighted to announce this year's winners of The FEBS Journal Richard Perham Prize and FEBS Letters Award

News from FEBS

Autophagy: The 2016 Nobel Prize – a celebratory article collection from FEBS Letters
Just out – a Virtual Issue in honour of FEBS Letters author Prof. Yoshinori Ohsumi!...

FEBS | EMBO Women in Science Award 2017

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Congratulations to the winners of the FEBS Anniversary Prizes 2016!

The awards recognize the achievements of young researchers invited to speak at a FEBS Congress...

Nominations open for the 2018 Biochemical Society Awards

There are three new awards this year...