FEBS PRESS

FEBS Press is pleased to welcome its fourth journal, Molecular Oncology, to this platform. Molecular Oncology is now fully Open Access and all content from the past 10 years is now available for all to read. The publication of high-quality journals by scientists for scientists is one the core objectives of The Federation of European Biochemical Societies (FEBS), with the revenue raised supporting fellowships, courses, congresses and other activities.

Journals Toggle

The FEBS Journal For high-quality full-length papers and reviews, with particular focus on biochemistry, molecular biology, structural biology and cell biology.
FEBS Letters For highly significant research letters that merit urgent publication, as well as timely reviews of wide interest in the molecular biosciences.
Molecular OncologyFor high-impact discoveries, approaches and technical advances in basic, clinical and discovery-driven translational cancer research.
FEBS Open Bio For rapid open access publication of scientifically sound research articles in the molecular and cellular life sciences.

Highlighted Articles

Argonaute 2 immunoprecipitation revealed large tumor suppressor kinase 1 as a novel proapoptotic target of miR-21 in T cells

Kluiver and colleagues, The FEBS Journal

MicroRNA (miR)-21 is a known suppressor of apoptosis in T cells, but its relevant targets have not been clearly identified. Using RNA-binding protein-immunoprecipitation followed by microarray profiling, Kluiver and colleagues identified the LATS1 gene, encoding a proapoptotic protein in the Hippo signalling pathway, as a miR-21 target. MiR-21 levels increased upon T-cell activation, with a concomitant decrease in LATS1 levels. Depletion of miR-21 induced apoptosis of T cells and LATS1 knockdown partially rescued this effect. This study suggests that LATS1 is the key target gene for the anti-apoptotic function of miR-21 in T cells.



Chronic systemic inflammation originating from epithelial tissues

Özge Uluçkan and Erwin F. Wagner, The FEBS Journal

Chronic systemic inflammation is a common contributor to many diseases. In this State-of-the-Art Review, Uluçkan and Wagner highlight chronic inflammation originating from skin and gut epithelial tissues, the role of the microbiome in pathogenesis and the secreted proinflammatory mediators that induce the common comorbidities that occur in chronic conditions such as psoriasis and inflammatory bowel disease.



Schwartz D. and colleagues

Cushing's syndrome mutant PKAL205R exhibits altered substrate specificity

Schwartz D. and colleagues, FEBS Letters

The L205R hotspot mutation in PKA has been associated with Cushing's syndrome. L205 may affect the interaction between the catalytic and regulatory subunits. Therefore, the L205R mutation has been hypothesized to result in a constitutively active enzyme. Thorough analysis now shows that this mutation alters substrate specificity. Thus, altered PKAL205R activity might not involve solely hyperphosphorylation of canonical substrates, but also inability to target some of them or recognition of new substrates.



Xu Y. and colleagues

Rab8A regulates insulin-stimulated GLUT4 translocation in C2C12 myoblasts

Xu Y. and colleagues, FEBS Letters

The glucose transporter GLUT4 is exocytosed in response to insulin. Among other Rab GTPases, Rab8A has been implicated in GLUT4 translocation in adipocytes and L6 myoblasts. Here, live cell imaging analysis combined with mutant and gene-silencing studies show that Rab8A is indispensable for GLUT4 translocation downstream of insulin signalling in C2C12 myoblasts.



Ciaudo and colleagues

Dicer, a new regulator of pluripotency exit and LINE-1 elements in mouse embryonic stem cells

Ciaudo and colleagues, FEBS Open Bio

Small RNAs produced by RNAse III DICER have emerged as key components within the gene regulation network responsible for coordinating processes that maintain cellular identity and genome integrity. Deletion of Dicer in mice leads to early embryonic lethality. Ciaudo and colleagues characterized Dicer-deficient mouse embryonic stem cells (mESCs), revealing impaired differentiation potential, incapacity to exit pluripotency state and an accumulation of LINE-1 (L1s) transcripts resulting in increased L1s retrotransposition. Their findings suggest Dicer to be fundamental in sustaining self-renewal of mESCs and genome integrity via L1s regulation.



FEBS Press News

This special issue focusses on the molecular mechanisms driving cancer metastasis

FEBS Open Bio is celebrating its 5th anniversary - take a look at their new Virtual Issues showcasing content in Cancer biology, Microbiology, Plant Biology, and Computational and Systems Biology

NobelRead the celebratory FEBS Letters Virtual Issue "Autophagy: The 2016 Nobel Prize" collecting studies by Yoshinori Ohsumi and his coworkers


This Virtual Issue showcases specially selected articles from the FEBS Press journals - The FEBS Journal, FEBS Letters and FEBS Open Bio - published in 2016

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