FEBS PRESS

FEBS Press is pleased to welcome its fourth journal, Molecular Oncology, to this platform. Molecular Oncology will become fully Open Access from 2017 and authors wishing to submit a paper, can do so here. The publication of high-quality journals by scientists for scientists is one the core objectives of The Federation of European Biochemical Societies (FEBS), with the revenue raised supporting fellowships, courses, congresses and other activities.

Journals Toggle

The FEBS Journal For high-quality full-length papers and reviews, with particular focus on biochemistry, molecular biology, structural biology and cell biology.
FEBS Letters For highly significant research letters that merit urgent publication, as well as timely reviews of wide interest in the molecular biosciences.
Molecular OncologyFor high-impact discoveries, approaches and technical advances in basic, clinical and discovery-driven translational cancer research.
FEBS Open Bio For rapid open access publication of scientifically sound research articles in the molecular and cellular life sciences.

Highlighted Articles

Sen1

Sen1, the homolog of human Senataxin, is critical for cell survival through regulation of redox homeostasis, mitochondrial function, and the TOR pathway in Saccharomyces cerevisiae

Tomar and colleagues, The FEBS Journal

Mutations in the human Senataxin (SETX) gene underlie several neurodegenerative disorders including amylotrophic lateral sclerosis 4 (ALS4), but the molecular mechanisms are yet to be fully uncovered. Using the conserved yeast Senataxin homolog Sen1, Tomar and colleagues show that mutants lacking the N-terminal domain are highly sensitive to oxidative stress and have a reduced unfolded protein response and mitochondrial membrane potential, providing a possible mechanism for the disorders associated with mutations in the human SETX gene.



The Stress Response

The stress response paradox: fighting degeneration at the cost of cancer

Sonja L. B. Arneaud and Peter M. Douglas, The FEBS Journal

Therapeutic strategies designed to treat different diseases can sometimes converge on the same cellular processes, making it challenging to reduce the pleiotropic effects of certain drugs. In this Viewpoint, Arneaud and Douglas highlight the activation of the unfolded protein response as a therapeutic strategy for treating neurodegenerative diseases and cancer, and call for a balanced approach when modulating stress response pathways in translational medicine.



Substrate profiling

Substrate profiling of Zika virus NS2B-NS3 protease

Krysztof Pyrc and colleagues, FEBS Letters

It was not until recently that the pathogenic potential of Zika virus, a member of the Flaviviridae family that had initially received little attention by researchers, was recognized. Here, the authors develop a system to screen for intracellular substrates of the Zika virus serine protease NS3. Given the central role of NS3 in viral replication, it is expected that this assay will assist the development of specific viral inhibitors.



Mutations in action

Mutations in actin used for structural studies partially disrupt β-thymosin/WH2 domains interaction

Carine van Heijenoort and colleages, FEBS Letters

Actin molecules carrying mutations that inhibit self-polymerization have often been used to facilitate structural studies of the cytoskeleton. However, through this Communication article, the authors question this practice by showing that such mutations alter the structure and internal dynamics of actin, affecting primarily interactions with intrinsically disordered proteins.



Paçó-Larson

Drosophila ataxin-2 gene encodes two differentially expressed isoforms and its function in larval fat body is crucial for development of peripheral tissues

Paçó-Larson and colleagues, FEBS Open Bio

Ataxin-2 isoforms are generic modiļ¬ers involved in a host of neurodegenerative diseases, but details of how the individual isoforms function in different cellular processes is poorly understood. Paçó-Larson and colleagues investigated the expression level and location of B and C isoforms of Ataxin-2 orthologs in developing Drosophila, gaining insight into their biological function and potential relevance to disease.



FEBS Press News

FEBS Open Bio is celebrating its 5th anniversary - take a look at their new Virtual Issues showcasing content in Cancer biology, Microbiology, Plant Biology, and Computational and Systems Biology

NobelRead the celebratory FEBS Letters Virtual Issue "Autophagy: The 2016 Nobel Prize" collecting studies by Yoshinori Ohsumi and his coworkers



This Virtual Issue showcases specially selected articles from the FEBS Press journals - The FEBS Journal, FEBS Letters and FEBS Open Bio - published in 2016


FEBS Press is delighted to announce this year's winners of The FEBS Journal Richard Perham Prize and the FEBS Letters Award

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