FEBS Press is pleased to welcome its fourth journal, Molecular Oncology, to this platform. Molecular Oncology is now fully Open Access and all content from the past 10 years is now available for all to read. The publication of high-quality journals by scientists for scientists is one the core objectives of The Federation of European Biochemical Societies (FEBS), with the revenue raised supporting fellowships, courses, congresses and other activities.

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The FEBS Journal For high-quality full-length papers and reviews, with particular focus on biochemistry, molecular biology, structural biology and cell biology.
FEBS Letters For highly significant research letters that merit urgent publication, as well as timely reviews of wide interest in the molecular biosciences.
Molecular OncologyFor high-impact discoveries, approaches and technical advances in basic, clinical and discovery-driven translational cancer research.
FEBS Open Bio For rapid open access publication of scientifically sound research articles in the molecular and cellular life sciences.

Highlighted Articles

Special Issue on Proteases and Proteolysis in Health and Disease

Special Issue on Proteases and Proteolysis in Health and Disease

The FEBS Journal

The FEBS Journal Special Issue on Proteases and Proteolysis in Health and Disease is out! Eleven specially commissioned reviews from experts in the field cover important and emerging topics in this diverse field, from protease deregulation in disease and protease-targeting drug development, to the latest methodologies in measuring protease activity. We are grateful to our authors for their contributions and hope you enjoy reading these reviews as much as we have!

Sciacovelli and Frezza

Metabolic reprogramming and epithelial-to-mesenchymal transition in cancer

Sciacovelli and Frezza, The FEBS Journal

Epithelial-to-mesenchymal transition (EMT) is a process whereby epithelial cancer cells acquire mesenchymal features that enable invasion and metastasis. This transformative process is associated with complex metabolic reprogramming. In this State-of-the-Art Review, Sciacovelli and Frezza highlight the underpinnings of metabolic rewiring during EMT and the interconnectivity between the metabolism and EMT activation.

Dewilde S. and colleagues

Impaired hypoxic tolerance in APP23 mice: a dysregulation of neuroprotective globin levels

Dewilde S. and colleagues, FEBS Letters

Neuroglobin (Ngb) and Cytoglobin (Cygb) may confer neuroprotection through their ROS-scavenging activity. In late-stage Alzheimer’s disease (AD), Ngb expression in the brain is downregulated. Here, using a mouse model of AD, the authors investigate whether whole body hypoxia as a secondary insult may downregulate globin expression in the brain through a mechanism involving the transcription factor REST.

Serrano, M.A. and colleagues

Detecting the Significant Flux Backbone of Escherichia coli metabolism

Serrano, M.A. and colleagues, FEBS Letters

Guëll et al. determine reaction fluxes in the metabolic network of E. coli using Flux Balance Analysis. Applying a disparity filter to preserve the complexity of the original network, the authors extract the Significant Flux Backbone (SFB), which reveals fingerprints of evolution and environmental adaptation.

Obayashi and colleagues

Multiple expression cassette exchange via TP901-1, R4 and Bxb1 integrase systems on a mouse artificial chromosome

Obayashi and colleagues, FEBS Open Bio

Here, Obayashi and colleagues created a reporter system to evaluate the precise target DNA excision for TP901-1, R4 and Bxb1 integrases, utilised in lineage tracing. In response to transient expression of specific integrases in hamster ovary cells, luciferase expression was exchanged for fluorescent protein expression – 3 distinct luciferases and 3 fluorescent proteins created up to 8 expression patterns. This reporter system was inserted into a mouse artificial chromosome vector. The multiple expression cassette exchange via site-speciļ¬c recombinases (MEEVS) platform explicated here could lead to complex genomic manipulations, not solely in tissue culture cells but in animals, yeast and plants - using combinations of SSRs, artificial chromosomes and other genome editing tools.


ZKSCAN1 gene and its related circular RNA (circZKSCAN1) both inhibit hepatocellular carcinoma cell growth, migration, and invasion but through different signaling pathways

Liu and colleagues, Molecular Oncology

There is increasing evidence to suggest that circular RNA (circRNA) are involved in cancer development, yet the regulation and function of human circRNA remains elusive. Here, Liu and colleagues demonstrate the linear and circular expression of ZKSCAN1, a zinc family gene, in human hepatocellular carcinoma (HCC) tissues and cell lines. Results reveal two post-translational products that cooperate via different pathways to inhibit growth, migration and invasion of HCC, with the suggestion that cirZKSCAN1 may prove to be a useful marker in HCC.

About FEBS Press

News about FEBS Press

Three FEBS Press journals – The FEBS Journal, FEBS Letters and FEBS Open Bio – award poster prizes at scientific meetings
This special issue focusses on the molecular mechanisms driving cancer metastasis

FEBS Open Bio is celebrating its 5th anniversary - take a look at their new Virtual Issues showcasing content in Cancer biology, Microbiology, Plant Biology, and Computational and Systems Biology

NobelRead the celebratory FEBS Letters Virtual Issue "Autophagy: The 2016 Nobel Prize" collecting studies by Yoshinori Ohsumi and his coworkers

This Virtual Issue showcases specially selected articles from the FEBS Press journals - The FEBS Journal, FEBS Letters and FEBS Open Bio - published in 2016

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