FEBS Press is pleased to welcome its fourth journal, Molecular Oncology, to this platform. Molecular Oncology is now fully Open Access and all content from the past 10 years is now available for all to read. The publication of high-quality journals by scientists for scientists is one the core objectives of The Federation of European Biochemical Societies (FEBS), with the revenue raised supporting fellowships, courses, congresses and other activities.
Argonaute 2 immunoprecipitation revealed large tumor suppressor kinase 1 as a novel proapoptotic target of miR-21 in T cells
Kluiver and colleagues, The FEBS Journal
MicroRNA (miR)-21 is a known suppressor of apoptosis in T cells, but its relevant targets have not been clearly identified. Using RNA-binding protein-immunoprecipitation followed by microarray profiling, Kluiver and colleagues identified the LATS1 gene, encoding a proapoptotic protein in the Hippo signalling pathway, as a miR-21 target. MiR-21 levels increased upon T-cell activation, with a concomitant decrease in LATS1 levels. Depletion of miR-21 induced apoptosis of T cells and LATS1 knockdown partially rescued this effect. This study suggests that LATS1 is the key target gene for the anti-apoptotic function of miR-21 in T cells.
Özge Uluçkan and Erwin F. Wagner, The FEBS Journal
Chronic systemic inflammation is a common contributor to many diseases. In this State-of-the-Art Review, Uluçkan and Wagner highlight chronic inflammation originating from skin and gut epithelial tissues, the role of the microbiome in pathogenesis and the secreted proinflammatory mediators that induce the common comorbidities that occur in chronic conditions such as psoriasis and inflammatory bowel disease.
Schwartz D. and colleagues, FEBS Letters
The L205R hotspot mutation in PKA has been associated with Cushing's syndrome. L205 may affect the interaction between the catalytic and regulatory subunits. Therefore, the L205R mutation has been hypothesized to result in a constitutively active enzyme. Thorough analysis now shows that this mutation alters substrate specificity. Thus, altered PKAL205R activity might not involve solely hyperphosphorylation of canonical substrates, but also inability to target some of them or recognition of new substrates.
Xu Y. and colleagues, FEBS Letters
The glucose transporter GLUT4 is exocytosed in response to insulin. Among other Rab GTPases, Rab8A has been implicated in GLUT4 translocation in adipocytes and L6 myoblasts. Here, live cell imaging analysis combined with mutant and gene-silencing studies show that Rab8A is indispensable for GLUT4 translocation downstream of insulin signalling in C2C12 myoblasts.
Ciaudo and colleagues, FEBS Open Bio
Small RNAs produced by RNAse III DICER have emerged as key components within the gene regulation network responsible for coordinating processes that maintain cellular identity and genome integrity. Deletion of Dicer in mice leads to early embryonic lethality. Ciaudo and colleagues characterized Dicer-deficient mouse embryonic stem cells (mESCs), revealing impaired differentiation potential, incapacity to exit pluripotency state and an accumulation of LINE-1 (L1s) transcripts resulting in increased L1s retrotransposition. Their findings suggest Dicer to be fundamental in sustaining self-renewal of mESCs and genome integrity via L1s regulation.
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Cancer biology, Microbiology, Plant Biology, and Computational and Systems Biology
- We congratulate FEBS Letters author Prof. Yoshinori Ohsumi on winning the 2016 Nobel Prize in Physiology or Medicine
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The February 2017 issue of FEBS News is out
A focus on the upcoming 42nd FEBS Congress, and lots more – enjoy browsing!..
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