FEBS Press is pleased to welcome its fourth journal, Molecular Oncology, to this platform. Molecular Oncology is now fully Open Access and all content from the past 10 years is now available for all to read. The publication of high-quality journals by scientists for scientists is one the core objectives of The Federation of European Biochemical Societies (FEBS), with the revenue raised supporting fellowships, courses, congresses and other activities.
Xiao and colleagues, The FEBS Journal
Polymerase ζ (Pol ζ), a translesion DNA synthesis (TLS) polymerase, bypasses UV-induced DNA lesions to prevent a blocked replication fork at the expense of absolute replication fidelity. Xiao and colleagues report that Rev7, a regulatory subunit of Pol ζ, is ubiquitinated and degraded in response to UV irradiation in a Cul4A/B (E3 ligase)-dependent manner. Intriguingly, the nucleotide excision repair (NER) pathway protein, HR23B, protects Rev7 from UV-mediated proteasomal degradation, revealing crosstalk between the error-prone TLS and the error-free NER pathways.
Clague and Urbé, The FEBS Journal
Reversible protein ubiquitination modulates protein homeostasis and is integrated within multiple cellular pathways and systems. Subcellular compartmentalisation results from differential membrane dynamics and trafficking patterns. In this State-of-the-Art Review, Clague and Urbé highlight the roles of the ubiquitin system, particularly deubiquitinating enzymes, in the regulation of endosomal sorting, selective autophagy and the secretory pathway.
Tonoplast (BvTIP1;2) and plasma membrane (BvPIP2;1) aquaporins show different mechanosensitive properties
Ozu, M. and colleagues, FEBS Letters
Cells rely on mechanosensitive ion channels to detect and respond to changes in hyperosmotic or hypo-osmotic conditions. Recently, it was shown that aquaporins — membrane proteins that transfer water molecules — may also display mechanosensitivity. Here, the authors show that the protoplast-derived aquaporin PIP2;1 does not respond to mechanical stimuli, whereas the tonoplast-derived aquaporin TIP1;2 does. The findings may reflect diversification during aquaporin evolution.
Identification and characterization of secreted factors that are upregulated during somatic cell reprogramming
Nakajima-Koyama, M. and colleagues, FEBS Letters
Cell reprogramming may be influenced by secreted factors. Here, Bansho et al. identify seven secreted factors that are upregulated during reprogramming of mouse embryonic fibroblasts (MEFs). Knockdown of Sostdc1, the secreted factor with the highest and earliest expression, reduces MEF reprogramming efficiency. Intriguingly, these factors are also upregulated during astrocyte reprogramming, suggesting a general phenomenon during somatic cell reprogramming.
The neuronal and astrocytic protein SLC38A10 transports glutamine, glutamate, and aspartate, suggesting a role in neurotransmission
Hellsten and colleagues, FEBS Open Bio
Within brain cells, glutamine transporters are essential for the monitoring and control of glutamate and GABA levels. Here, Hellsten and colleagues report the first histological and functional characterisation of SLC38A10, a previous orphan member of the SLC38 family of amino acid transporters. SLC38A10 immunostaining was abundant in the mouse brain, showing colocalised staining with markers for neurons and astrocytes. Transport assays suggest the transporter is bidirectional and can mediate uptake and efflux of multiple neurotransmitters. Together, these studies suggest that SLC38A10 may potentially play a role in excitatory and inhibitory neurotransmission.
ZKSCAN1 gene and its related circular RNA (circZKSCAN1) both inhibit hepatocellular carcinoma cell growth, migration, and invasion but through different signaling pathways
Liu and colleagues, Molecular Oncology
There is increasing evidence to suggest that circular RNA (circRNA) are involved in cancer development, yet the regulation and function of human circRNA remains elusive. Here, Liu and colleagues demonstrate the linear and circular expression of ZKSCAN1, a zinc family gene, in human hepatocellular carcinoma (HCC) tissues and cell lines. Results reveal two post-translational products that cooperate via different pathways to inhibit growth, migration and invasion of HCC, with the suggestion that cirZKSCAN1 may prove to be a useful marker in HCC.
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- We congratulate FEBS Letters author Prof. Yoshinori Ohsumi on winning the 2016 Nobel Prize in Physiology or Medicine
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