FEBS Press is pleased to welcome its fourth journal, Molecular Oncology, to this platform. Molecular Oncology will become fully Open Access from 2017 and authors wishing to submit a paper, can do so here. The publication of high-quality journals by scientists for scientists is one the core objectives of The Federation of European Biochemical Societies (FEBS), with the revenue raised supporting fellowships, courses, congresses and other activities.
Sen1, the homolog of human Senataxin, is critical for cell survival through regulation of redox homeostasis, mitochondrial function, and the TOR pathway in Saccharomyces cerevisiae
Tomar and colleagues, The FEBS Journal
Mutations in the human Senataxin (SETX) gene underlie several neurodegenerative disorders including amylotrophic lateral sclerosis 4 (ALS4), but the molecular mechanisms are yet to be fully uncovered. Using the conserved yeast Senataxin homolog Sen1, Tomar and colleagues show that mutants lacking the N-terminal domain are highly sensitive to oxidative stress and have a reduced unfolded protein response and mitochondrial membrane potential, providing a possible mechanism for the disorders associated with mutations in the human SETX gene.
Sonja L. B. Arneaud and Peter M. Douglas, The FEBS Journal
Therapeutic strategies designed to treat different diseases can sometimes converge on the same cellular processes, making it challenging to reduce the pleiotropic effects of certain drugs. In this Viewpoint, Arneaud and Douglas highlight the activation of the unfolded protein response as a therapeutic strategy for treating neurodegenerative diseases and cancer, and call for a balanced approach when modulating stress response pathways in translational medicine.
Krysztof Pyrc and colleagues, FEBS Letters
It was not until recently that the pathogenic potential of Zika virus, a member of the Flaviviridae family that had initially received little attention by researchers, was recognized. Here, the authors develop a system to screen for intracellular substrates of the Zika virus serine protease NS3. Given the central role of NS3 in viral replication, it is expected that this assay will assist the development of specific viral inhibitors.
Carine van Heijenoort and colleages, FEBS Letters
Actin molecules carrying mutations that inhibit self-polymerization have often been used to facilitate structural studies of the cytoskeleton. However, through this Communication article, the authors question this practice by showing that such mutations alter the structure and internal dynamics of actin, affecting primarily interactions with intrinsically disordered proteins.
Drosophila ataxin-2 gene encodes two differentially expressed isoforms and its function in larval fat body is crucial for development of peripheral tissues
Paçó-Larson and colleagues, FEBS Open Bio
Ataxin-2 isoforms are generic modiﬁers involved in a host of neurodegenerative diseases, but details of how the individual isoforms function in different cellular processes is poorly understood. Paçó-Larson and colleagues investigated the expression level and location of B and C isoforms of Ataxin-2 orthologs in developing Drosophila, gaining insight into their biological function and potential relevance to disease.
FEBS Press NewsCancer biology, Microbiology, Plant Biology, and Computational and Systems Biology
- We congratulate FEBS Letters author Prof. Yoshinori Ohsumi on winning the 2016 Nobel Prize in Physiology or Medicine
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The November 2016 issue of FEBS News is out
A smorgasbord of content from FEBS activities and the FEBS community... Have a look!...
FEBS Advanced Courses 2017
Course summaries are now on the website, and organizers are starting to open registrations – enjoy browsing this year's list!...
Autophagy: The 2016 Nobel Prize – a celebratory article collection from FEBS Letters
Just out – a Virtual Issue in honour of FEBS Letters author Prof. Yoshinori Ohsumi!...