FEBS Press is pleased to welcome its fourth journal, Molecular Oncology, to this platform. Molecular Oncology will become fully Open Access from 2017 and authors wishing to submit a paper, can do so here. The publication of high-quality journals by scientists for scientists is one the core objectives of The Federation of European Biochemical Societies (FEBS), with the revenue raised supporting fellowships, courses, congresses and other activities.

Journals Toggle

The FEBS Journal For high-quality full-length papers and reviews, with particular focus on biochemistry, molecular biology, structural biology and cell biology.
FEBS Letters For highly significant research letters that merit urgent publication, as well as timely reviews of wide interest in the molecular biosciences.
Molecular OncologyFor high-impact discoveries, approaches and technical advances in basic, clinical and discovery-driven translational cancer research.
FEBS Open Bio For rapid open access publication of scientifically sound research articles in the molecular and cellular life sciences.

Highlighted Articles

L16 60S

Role of the yeast ribosomal protein L16 in ribosome biogenesis

Jesús de la Cruz and colleagues (2016), The FEBS Journal

Ribosomal biogenesis is a highly coordinated process involving a large number of proteins. Using the yeast genetics toolset, de la Cruz and colleagues provide molecular details on the essential role of the ribosomal protein L16 in the assembly of the 60S subunit. This study also consolidates previous major findings involving the mammalian orthologue of yeast L16 protein.

12 Flavours of AMPK

AMP-activated protein kinase: a cellular energy sensor that comes in 12 flavours

Hardie and colleagues (2016), The FEBS Journal

The AMP-activated protein kinase (AMPK) is a central energy sensor found in all eukaryotes as a trimeric complex. In this State-of-the-Art Review, Hardie and colleagues present a comprehensive overview of the structural features of the AMPK isoforms, their evolutionary origins and functional regulation and discuss emerging roles in cancer development.

B-side electron transfer

Species differences in unlocking B-side electron transfer in bacterial reaction centers

Philip D. Laible and colleagues, FEBS Letters

During photosynthesis light is converted into chemical energy at reaction centers (RCs). RCs consist of a transmembrane complex combined with cofactors that are arranged symmetrically across two paths of electron transfer (ET) — the A-side and the B-side ET pathways. In type II RCs (typical of purple bacteria), the A-side ET pathway is active, whereas the B-side ET pathway is suppressed. Here, the authors employ a new high-throughput approach to generate structural RC variants, and reveal that the B-side ET pathways of the highly homologous RCs of two Rhodobacter species are likely to be suppressed through distinct mechanisms.

Reaction pathways

Direct protein–protein interactions and substrate channeling between cellular retinoic acid binding proteins and CYP26B1

Nina Isoherranen and colleagues, FEBS Letters

All-trans-retinoic acid (atRA), the main active metabolite of vitamin A, is known to bind to the soluble cytosolic carrier proteins CRAB-I and CRAB-II. This study indicates that CRAB-I and CRAB-II deliver the atRA substrate to the ER-resident atRA-catabolizing enzyme CYP26B1. The authors speculate that other fat-soluble substrates may also be delivered for catabolism to cytochrome P450 (CYP) enzymes by soluble cytosolic carrier proteins.

Brain Injury

Traumatic brain injury increases levels of miR-21 in extracellular vesicles: implications for neuroinflammation

Sowmya Yelamanchili and colleagues, FEBS Open Bio

Effective treatment strategies for traumatic brain injury (TBI) remain elusive. Cell–cell communication is critical in TBI and extracellular vesicles (EVs) are known to carry cargo between cells. Harrison and colleagues found that TBI induced global changes in the miRNA content of brain‐derived EVs, with miR‐21 showing the largest increase. Expression of miR-21 was primarily localized to neurons near the lesion site. These findings indicate that miR‐21 may play a crucial role in cell–cell communication after brain injury.

FEBS Press News

Click the below button to submit your Open Access paper!

This Virtual Issue showcases specially selected articles from the FEBS Press journals – The FEBS Journal, FEBS Letters and FEBS Open Bio - published in 2016

FEBS Press is delighted to announce this year's winners of The FEBS Journal Richard Perham Prize and FEBS Letters Award
Structural Snapshots present succinct discussions of biologically important structures...

News from FEBS

The FEBS 2016 Congress is cancelled

The FEBS Executive Committee are very sorry to announce that the FEBS Congress in Kuşadasi from 3rd to 8th September is cancelled...

The July 2016 issue of FEBS News is out!

From fellowships to events to journals – enjoy a snapshot of current FEBS activities ...

FEBS Fellowships call 2016 is now open

Apply before 1 October 2016 for FEBS Long-Term and Return-to-Europe Fellowships...

Upcoming FEBS Workshops 2016

Apply now for workshops on Coenzyme A and on Chromatin proteomics...